Endogenous opioid peptides and the control of pain

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Endogenous opioid peptides and the control of pain.

After a brief discussion of physiologic bases of pain sensation, particularly with respect to central mechanisms of integration and control of nociceptive impulses, emphasis is centered on the possible existence of endogenous opioid systems functioning effectively to control pain in humans. Inducement of stress and certain techniques for applying stimuli of the electroacupuncture type activate ...

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Neuropathic pain often results from peripheral nerve damage, which can involve immune response. Local leukocyte-derived opioid peptides or exogenous opioid agonists inhibit neuropathy-induced mechanical hypersensitivity in animal models. Since neuropathic pain can also be augmented by heat, in this study we investigated the role of opioids in the modulation of neuropathy-evoked heat hypersensit...

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Opioid peptides in peripheral pain control.

Opioids have a long history of therapeutic use as a remedy for various pain states ranging from mild acute nociceptive pain to unbearable chronic advanced or end-stage disease pain. Analgesia produced by classical opioids is mediated extensively by binding to opioid receptors located in the brain or the spinal cord. Nevertheless, opioid receptors are also expressed outside the CNS in the periph...

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T HE DISCOVERY, in 1973, of specific opiate receptors in the brain and, later, in the pituitary, sympathetic ganglia, kidney, liver, gastrointestinal tract, and heart suggested that there were endogenous substances that interacted specifically with these receptors.“’ Subsequently, a series of compounds that exhibited specific binding to these receptors were isolated from different tissues, incl...

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Introduction: Some evidence demonstrates endogenous inhibitory pathways of pain involved in the interphase (phase between early and later phase) of the formalin test. We previously showed that swimming stress modulates the pain-related behaviors during the interphase of the formalin test. In this study, we evaluated the role of the endogenous opioid system in modulating nociceptive responses of...

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ژورنال

عنوان ژورنال: Psychological Medicine

سال: 1979

ISSN: 0033-2917,1469-8978

DOI: 10.1017/s0033291700021498